Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects

Genetic variants are the primary driver of congenital heart disease (CHD) pathogenesis. However, our ability to identify causative variants is limited. To identify causal CHD genes that are associated with specific molecular functions, the study used prior knowledge to filter de novo variants from 2...

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Bibliografiska uppgifter
I publikationen:JACC Basic Transl Sci
Huvudupphovsmän: Edwards, Jonathan J., Rouillard, Andrew D., Fernandez, Nicolas F., Wang, Zichen, Lachmann, Alexander, Shankaran, Sunita S., Bisgrove, Brent W., Demarest, Bradley, Turan, Nahid, Srivastava, Deepak, Bernstein, Daniel, Deanfield, John, Giardini, Alessandro, Porter, George, Kim, Richard, Roberts, Amy E., Newburger, Jane W., Goldmuntz, Elizabeth, Brueckner, Martina, Lifton, Richard P., Seidman, Christine E., Chung, Wendy K., Tristani-Firouzi, Martin, Yost, H. Joseph, Ma’ayan, Avi, Gelb, Bruce D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2020
Ämnen:
PRECLINICAL RESEARCH
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188873/
https://ncbi.nlm.nih.gov/pubmed/32368696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2020.01.012
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