Prolonged Persistence of Chimeric Antigen Receptor (CAR) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward

CAR T cell qualities, such as persistence and functionality play important roles in determining the outcome of cancer immunotherapy. In spite of full functionality, it has been shown that poor persistence of CAR T cells can limit an effective antitumor immune response. Here, we outline specific stra...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Jafarzadeh, Leila, Masoumi, Elham, Fallah-Mehrjardi, Keyvan, Mirzaei, Hamid Reza, Hadjati, Jamshid
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188834/
https://ncbi.nlm.nih.gov/pubmed/32391013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00702
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