Characterization of doxycycline-mediated inhibition of Marfan syndrome-associated aortic dilation by multiphoton microscopy

Marfan syndrome (MFS) is a connective tissue disorder that results in aortic root widening and aneurysm if unmanaged. We have previously reported doxycycline, a nonselective matrix metalloproteinases (MMPs) inhibitor, to attenuate aortic root widening and improve aortic contractility and elasticity...

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Udgivet i:Sci Rep
Main Authors: Tehrani, Arash Y., Cui, Jason Z., Bucky Jones, T., Hotova, Ester, Castro, Monica, Bernatchez, Pascal, van Breemen, Cornelis, Esfandiarei, Mitra
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188819/
https://ncbi.nlm.nih.gov/pubmed/32346027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64071-8
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