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Sildenafil Prevents Marfan-Associated Emphysema and Early Pulmonary Artery Dilation in Mice

Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in fibrillin-1 (Fbn1). Although aortic rupture is the major cause of mortality in MFS, patients also experience pulmonary complications, which are poorly understood. Loss of basal nitric oxide (NO) production and vascular inte...

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Dettagli Bibliografici
Pubblicato in:Am J Pathol
Autori principali: White, Zoe, Milad, Nadia, Tehrani, Arash Y., Lamothe, Jennifer, Hogg, James C., Esfandiarei, Mitra, Seidman, Michael, Booth, Steven, Hackett, Tillie-Louise, Morissette, Mathieu C., Bernatchez, Pascal
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997843/
https://ncbi.nlm.nih.gov/pubmed/31125551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.05.003
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