Angiotensin II receptor blocker losartan exacerbates muscle damage and exhibits weak blood pressure-lowering activity in a dysferlin-null model of Limb-Girdle muscular dystrophy type 2B

There is no cure or beneficial management option for Limb-Girdle muscular dystrophy (MD) type 2B (LGMD2B). Losartan, a blood pressure (BP) lowering angiotensin II (AngII) receptor type 1 (ATR1) blocker (ARB) with unique anti-transforming growth factor-β (TGF-β) properties, can protect muscles in var...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: White, Zoe, Milad, Nadia, Tehrani, Arash Y., Chen, William Wei-Han, Donen, Graham, Sellers, Stephanie L., Bernatchez, Pascal
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690544/
https://ncbi.nlm.nih.gov/pubmed/31404091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220903
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