Cycloartane triterpenoid (23R, 24E)-23-acetoxymangiferonic acid inhibited proliferation and migration in B16-F10 melanoma via MITF downregulation caused by inhibition of both β-catenin and c-Raf–MEK1–ERK signaling axis

We recently reported that (23R, 24E)-23-acetoxymangiferonic acid (23R-AMA), a cycloartane triterpenoid isolated by activity-guided separation from a methanol extract of Garcinia sp. bark, inhibited melanin production via inhibition of tyrosinase (TYR) expression in the B16-F10 melanoma cell line. Si...

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Bibliographic Details
Published in:J Nat Med
Main Authors: Kaneda, Toshio, Matsumoto, Misaki, Sotozono, Yayoi, Fukami, Satoshi, Nugroho, Alfarius Eko, Hirasawa, Yusuke, Hamid A, Hadi A., Morita, Hiroshi
Format: Artigo
Language:Inglês
Published: Springer Singapore 2018
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188735/
https://ncbi.nlm.nih.gov/pubmed/30084054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11418-018-1233-7
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