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Sorafenib administered using a high-dose, pulsatile regimen in patients with advanced solid malignancies: a phase I exposure escalation study

BACKGROUND: (Pre)clinical evidence is accumulating that intermittent exposure to increased doses of protein kinase inhibitors may improve their treatment benefit. In this phase I trial, the safety of high-dose, pulsatile sorafenib was studied. PATIENTS AND METHODS: High-dose sorafenib was administer...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Mammatas, L. H., Zandvliet, A. S., Rovithi, M., Honeywell, R. J., Swart, E. L., Peters, G. J., Menke-van der Houven van Oordt, C. W., Verheul, H. M. W.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188706/
https://ncbi.nlm.nih.gov/pubmed/32274565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-020-04065-5
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