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Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression
The best-known role of UDP-glucuronosyltransferase enzymes (UGTs) in cancer is the metabolic inactivation of drug therapies. By conjugating glucuronic acid to lipophilic drugs, UGTs impair the biological activity and enhance the water solubility of these agents, driving their elimination. Multiple c...
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| Опубликовано в: : | Br J Cancer |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7188667/ https://ncbi.nlm.nih.gov/pubmed/32047295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0722-0 |
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