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Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression
The best-known role of UDP-glucuronosyltransferase enzymes (UGTs) in cancer is the metabolic inactivation of drug therapies. By conjugating glucuronic acid to lipophilic drugs, UGTs impair the biological activity and enhance the water solubility of these agents, driving their elimination. Multiple c...
Guardado en:
| Publicado en: | Br J Cancer |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7188667/ https://ncbi.nlm.nih.gov/pubmed/32047295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0722-0 |
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