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Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression
The best-known role of UDP-glucuronosyltransferase enzymes (UGTs) in cancer is the metabolic inactivation of drug therapies. By conjugating glucuronic acid to lipophilic drugs, UGTs impair the biological activity and enhance the water solubility of these agents, driving their elimination. Multiple c...
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| Publicado no: | Br J Cancer |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7188667/ https://ncbi.nlm.nih.gov/pubmed/32047295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0722-0 |
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