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Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression

The best-known role of UDP-glucuronosyltransferase enzymes (UGTs) in cancer is the metabolic inactivation of drug therapies. By conjugating glucuronic acid to lipophilic drugs, UGTs impair the biological activity and enhance the water solubility of these agents, driving their elimination. Multiple c...

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Detalles Bibliográficos
Publicado en:Br J Cancer
Autores principales: Allain, Eric P., Rouleau, Michèle, Lévesque, Eric, Guillemette, Chantal
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188667/
https://ncbi.nlm.nih.gov/pubmed/32047295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0722-0
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