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Cyclin-Dependent Kinase 4 inhibits the translational repressor 4E-BP1 to promote cap-dependent translation during mitosis–G1 transition

Phosphorylation of translational repressor eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) controls the initiation of cap-dependent translation, a type of protein synthesis that is frequently upregulated in human diseases such as cancer. Because of its critical cellula...

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Vydáno v:FEBS Lett
Hlavní autoři: Mitchell, Dylan C., Menon, Arya, Garner, Amanda L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188594/
https://ncbi.nlm.nih.gov/pubmed/31853978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13721
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