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PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis
BACKGROUND AND PURPOSE: Ischemic stroke impairs endoplasmic reticulum (ER) function, causes ER stress, and activates the unfolded protein response (UPR). The UPR consists of 3 branches controlled by ER stress sensor proteins, which include protein kinase RNA-like ER kinase (PERK). Activated PERK pho...
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| Publicado no: | Stroke |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7188566/ https://ncbi.nlm.nih.gov/pubmed/32212900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.120.029071 |
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