Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats

Sedatives are suspected contributors to neurologic dysfunction in PICU patients, to whom they are administered during sensitive neurodevelopment. Relevant preclinical modeling has largely used comparatively brief anesthesia in infant age-approximate animals, with insufficient study of repetitive com...

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Detalhes bibliográficos
Publicado no:Crit Care Explor
Main Authors: Iqbal O’Meara, Alia Marie, Miller Ferguson, Nikki, Zven, Sidney E., Karam, Oliver L., Meyer, Logan C., Bigbee, John W., Sato-Bigbee, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Health 2020
Assuntos:
Original Basic Science Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188419/
https://ncbi.nlm.nih.gov/pubmed/32426747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCE.0000000000000105
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