Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats

Sedatives are suspected contributors to neurologic dysfunction in PICU patients, to whom they are administered during sensitive neurodevelopment. Relevant preclinical modeling has largely used comparatively brief anesthesia in infant age-approximate animals, with insufficient study of repetitive com...

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Dades bibliogràfiques
Publicat a:Crit Care Explor
Autors principals: Iqbal O’Meara, Alia Marie, Miller Ferguson, Nikki, Zven, Sidney E., Karam, Oliver L., Meyer, Logan C., Bigbee, John W., Sato-Bigbee, Carmen
Format: Artigo
Idioma:Inglês
Publicat: Wolters Kluwer Health 2020
Matèries:
Original Basic Science Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188419/
https://ncbi.nlm.nih.gov/pubmed/32426747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCE.0000000000000105
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