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Efficacy of Humanized Cefiderocol Exposure Is Unaltered by Host Iron Overload in the Thigh Infection Model

Cefiderocol is a siderophore-cephalosporin conjugate with greater in vitro potency under iron-depleted conditions. During infection, iron is scarce in host tissue; however, it is not known whether iron overload in the host, such as in cases of hereditary hemochromatosis, alters the efficacy of cefid...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Kidd, James M., Abdelraouf, Kamilia, Nicolau, David P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187581/
https://ncbi.nlm.nih.gov/pubmed/31658966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01767-19
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