Changes in cellular Ca(2+) and Na(+) regulation during the progression towards heart failure in the guinea pig

KEY POINTS: During compensated hypertrophy in vivo fractional shortening (FS) remains constant until heart failure (HF) develops, when FS decreases from 70% to 39%. Compensated hypertrophy is accompanied by an increase in I (Na,late) and a decrease in Na(+),K(+)‐ATPase current. These changes persist...

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Pubblicato in:J Physiol
Autori principali: Ke, H.‐Y., Yang, H.‐Y., Francis, A. J., Collins, T. P., Surendran, H., Alvarez‐Laviada, A., Firth, J. M., MacLeod, K. T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187457/
https://ncbi.nlm.nih.gov/pubmed/30811606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277038
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