N(α)-Acetylation of the virulence factor EsxA is required for mycobacterial cytosolic translocation and virulence

The Mycobacterium tuberculosis virulence factor EsxA and its chaperone EsxB are secreted as a heterodimer (EsxA:B) and are crucial for mycobacterial escape from phagosomes and cytosolic translocation. Current findings support the idea that for EsxA to interact with host membranes, EsxA must dissocia...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Aguilera, Javier, Karki, Chitra B., Li, Lin, Vazquez Reyes, Salvador, Estevao, Igor, Grajeda, Brian I., Zhang, Qi, Arico, Chenoa D., Ouellet, Hugues, Sun, Jianjun
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186180/
https://ncbi.nlm.nih.gov/pubmed/32169899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012497
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