N(α)-Acetylation of the virulence factor EsxA is required for mycobacterial cytosolic translocation and virulence

The Mycobacterium tuberculosis virulence factor EsxA and its chaperone EsxB are secreted as a heterodimer (EsxA:B) and are crucial for mycobacterial escape from phagosomes and cytosolic translocation. Current findings support the idea that for EsxA to interact with host membranes, EsxA must dissocia...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Aguilera, Javier, Karki, Chitra B., Li, Lin, Vazquez Reyes, Salvador, Estevao, Igor, Grajeda, Brian I., Zhang, Qi, Arico, Chenoa D., Ouellet, Hugues, Sun, Jianjun
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2020
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186180/
https://ncbi.nlm.nih.gov/pubmed/32169899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012497
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires