EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5

EsxA is required for virulence of Mycobacterium tuberculosis (Mtb) and plays an essential role in phagosome rupture and translocation to the cytosol of macrophages. Recent biochemical studies have demonstrated that EsxA is a membrane-permeabilizing protein. However, evidence that link EsxA membrane-...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Zhang, Qi, Wang, Decheng, Jiang, Guozhong, Liu, Wei, Deng, Qing, Li, Xiujun, Qian, Wei, Ouellet, Hugues, Sun, Jianjun
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013644/
https://ncbi.nlm.nih.gov/pubmed/27600772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32618
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