SPOP is essential for DNA–protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex

SPOP, speckle-type POZ protein is a substrate adaptor protein of the Cullin-3/RING ubiquitin E3 complex. The spop gene is the most commonly point mutated in human primary prostate cancers, but the pathological contribution of the SPOP mutations remains unclear. In this study, we investigated several...

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Bibliographic Details
Published in:Mol Biol Cell
Main Authors: Watanabe, Ryuta, Maekawa, Masashi, Hieda, Miki, Taguchi, Tomohiko, Miura, Noriyoshi, Kikugawa, Tadahiko, Saika, Takashi, Higashiyama, Shigeki
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2020
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185892/
https://ncbi.nlm.nih.gov/pubmed/31967940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-08-0456
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