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Targeting the viral Achilles’ heel: recognition of 5′-triphosphate RNA in innate anti-viral defence
Some RNA virus genomes bear 5′-triphosphates, which can be recognized in the cytoplasm of infected cells by host proteins that mediate anti-viral immunity. Both the innate sensor RIG-I and the interferon-induced IFIT proteins bind to 5′-triphosphate viral RNAs. RIG-I signals for induction of interfe...
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| Gepubliceerd in: | Curr Opin Microbiol |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Elsevier Ltd.
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7185528/ https://ncbi.nlm.nih.gov/pubmed/23707340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mib.2013.04.009 |
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