Potently cytotoxic natural killer cells initially emerge from erythro-myeloid progenitors during mammalian development

Natural Killer (NK) cells are a critical component of the innate immune system. However, their ontogenic origin has remained unclear. Here we report that NK cell potential first arises from Hoxa(neg/low) Kit(+)CD41(+)CD16/32(+) hematopoietic stem cell (HSC)-independent erythro-myeloid progenitors (E...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Dege, Carissa, Fegan, Katherine H., Creamer, J. Philip, Berrien-Elliott, Melissa M., Luff, Stephanie A., Kim, Darren, Wagner, Julia A., Kingsley, Paul D., McGrath, Kathleen E., Fehniger, Todd A., Palis, James, Sturgeon, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185477/
https://ncbi.nlm.nih.gov/pubmed/32197069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.02.016
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