Short Communication: Metformin Reduces CD4 T Cell Exhaustion in HIV-Infected Adults on Suppressive Antiretroviral Therapy

Increased negative immune checkpoint receptors (NCR) on T cells are linked to T cell exhaustion, dysfunctional effector responses, and HIV viral persistence. Metformin, an oral hypoglycemic agent used for diabetes, may have previously unrecognized beneficial immunologic effects. Using cryopreserved...

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Dettagli Bibliografici
Pubblicato in:AIDS Res Hum Retroviruses
Autori principali: Shikuma, Cecilia M., Chew, Glen M., Kohorn, Lindsay, Souza, Scott A., Chow, Dominic, SahBandar, Ivo Novita, Park, Eun-Young, Hanks, Nancy, Gangcuangco, Louie Mar A., Gerschenson, Mariana, Ndhlovu, Lishomwa C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc., publishers 2020
Soggetti:
Outcomes Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185314/
https://ncbi.nlm.nih.gov/pubmed/31731885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2019.0078
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