Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90(+) (myo-)fibroblasts in Crohn’s disease and regulate T(h)1/T(h)17 cell responses

Increased T helper (T(h))1/T(h)17 immune responses are a hallmark of Crohn’s disease (CD) immunopathogenesis. CD90(+) (myo-)fibroblasts (MFs) are abundant cells in the normal (N) intestinal mucosa contributing to mucosal tolerance via suppression of T(h)1 cell activity through cell surface membrane-...

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Detalles Bibliográficos
Publicado en:Int Immunol
Main Authors: Aguirre, Jose E, Beswick, Ellen J, Grim, Carl, Uribe, Gabriela, Tafoya, Marissa, Chacon Palma, Gabriela, Samedi, Von, McKee, Rohini, Villeger, Romain, Fofanov, Yuriy, Cong, Yingzi, Yochum, Gregory, Koltun, Walter, Powell, Don, Pinchuk, Irina V
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185192/
https://ncbi.nlm.nih.gov/pubmed/31633754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxz060
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