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Reprogrammed CRISPR-Cas13a targeting the HPV16/18 E6 gene inhibits proliferation and induces apoptosis in E6-transformed keratinocytes

The long-lasting infection of high-risk type (type 16 or type 18) human papillomavirus (HPV) is the main cause of gynecological and urinary malignancies. Given the high mortality rate after surgery, the development of a new molecular therapy would be of value to clinicians. The aim of the present st...

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Bibliografski detalji
Izdano u:Exp Ther Med
Glavni autori: Li, Chunjing, Guo, Liwen, Liu, Guoqing, Guo, Mingjuan, Wei, Huiling, Yang, Qiqiong, Wang, Jianfeng, Chen, Huihua
Format: Artigo
Jezik:Inglês
Izdano: D.A. Spandidos 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185167/
https://ncbi.nlm.nih.gov/pubmed/32346451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2020.8631
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