Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease

Atrophic A\age-related macular degeneration (AMD) and Stargardt disease (STGD) are major blinding diseases affecting millions of patients worldwide, but no treatment is available. In dry AMD and STGD oxidative stress and subretinal accumulation of N-retinylidene-N-retinylethanolamine (A2E), a toxic...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Fontaine, Valérie, Monteiro, Elodie, Fournié, Mylène, Brazhnikova, Elena, Boumedine, Thinhinane, Vidal, Cécile, Balducci, Christine, Guibout, Louis, Latil, Mathilde, Dilda, Pierre J., Veillet, Stanislas, Sahel, José-Alain, Lafont, René, Camelo, Serge
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185133/
https://ncbi.nlm.nih.gov/pubmed/32255762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103014
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