Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease

Atrophic A\age-related macular degeneration (AMD) and Stargardt disease (STGD) are major blinding diseases affecting millions of patients worldwide, but no treatment is available. In dry AMD and STGD oxidative stress and subretinal accumulation of N-retinylidene-N-retinylethanolamine (A2E), a toxic...

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Enregistré dans:
Détails bibliographiques
Publié dans:Aging (Albany NY)
Auteurs principaux: Fontaine, Valérie, Monteiro, Elodie, Fournié, Mylène, Brazhnikova, Elena, Boumedine, Thinhinane, Vidal, Cécile, Balducci, Christine, Guibout, Louis, Latil, Mathilde, Dilda, Pierre J., Veillet, Stanislas, Sahel, José-Alain, Lafont, René, Camelo, Serge
Format: Artigo
Langue:Inglês
Publié: Impact Journals 2020
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185133/
https://ncbi.nlm.nih.gov/pubmed/32255762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103014
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