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Regulation of pancreatic cancer TRAIL resistance by protein O-GlcNAcylation

TRAIL-activating therapy is promising in treating various cancers, including pancreatic cancer, a highly malignant neoplasm with poor prognosis. However, many pancreatic cancer cells are resistant to TRAIL-induced apoptosis despite their expression of intact death receptors (DRs). Protein O-GlcNAcyl...

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Detalhes bibliográficos
Publicado no:Lab Invest
Main Authors: Yang, Shan-zhong, Xu, Fei, Yuan, Kaiyu, Sun, Yong, Zhou, Tong, Zhao, Xinyang, McDonald, Jay M, Chen, Yabing
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183418/
https://ncbi.nlm.nih.gov/pubmed/31896813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-019-0365-z
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