Triple Drugs Co-Delivered by a Small Gemcitabine-Based Carrier for Pancreatic Cancer Immunochemotherapy

Poor tumor penetration and highly immunosuppressive tumor microenvironment are two major factors that limit the therapeutic efficacy for the treatment of pancreatic ductal adenocarcinoma (PDA). In this work, a redox-responsive gemcitabine (GEM)-conjugated polymer, PGEM, was employed as a tumor penet...

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Pubblicato in:Acta Biomater
Autori principali: Sun, Jingjing, Wan, Zhuoya, Chen, Yichao, Xu, Jieni, Luo, Zhangyi, Parise, Robert A., Diao, Dingwei, Ren, Pengfei, Beumer, Jan H., Lu, Binfeng, Li, Song
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183357/
https://ncbi.nlm.nih.gov/pubmed/32004652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2020.01.039
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