The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA

The vast majority of type 1 diabetes (T1D) genetic association signals lie in noncoding regions of the human genome. Many have been predicted to affect the expression and secondary structure of long noncoding RNAs (lncRNAs), but the contribution of these lncRNAs to the pathogenesis of T1D remains to...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Gonzalez-Moro, Itziar, Olazagoitia-Garmendia, Ane, Colli, Maikel L., Cobo-Vuilleumier, Nadia, Postler, Thomas S., Marselli, Lorella, Marchetti, Piero, Ghosh, Sankar, Gauthier, Benoit R., Eizirik, Decio L., Castellanos-Rubio, Ainara, Santin, Izortze
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2020
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183221/
https://ncbi.nlm.nih.gov/pubmed/32284404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914353117
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