A homozygous nonsense mutation of PLCZ1 cause male infertility with oocyte activation deficiency

PURPOSE: To identify the pathogenic PLCZ1 mutation involved in male infertility and fertilization failure. METHODS: All coding regions of PLCZ1 were sequenced by Sanger sequencing. The expression and localization of PLCZ1 in sperm was determined by Western blotting and immunofluorescence. To promote...

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Detalhes bibliográficos
Publicado no:J Assist Reprod Genet
Main Authors: Wang, Fengsong, Zhang, Jingjing, Kong, Shuai, Li, Chanjuan, Zhang, Zhiguo, He, Xiaojin, Wu, Huan, Tang, Dongdong, Zha, Xiaomin, Tan, Qing, Duan, Zongliu, Cao, Yunxia, Zhu, Fuxi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2020
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183032/
https://ncbi.nlm.nih.gov/pubmed/32146562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-020-01719-4
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