Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells

Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal and differentiation of neural precursor cells (NPCs) in the developing mammalian brain. However, little is known about how metabolic signals instruct gene expression to control NPC homeostasis. Here, we sho...

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Vydáno v:Nat Commun
Hlavní autoři: Rodrigues, Deivid Carvalho, Harvey, Emily M., Suraj, Rejitha, Erickson, Sarah L., Mohammad, Lamees, Ren, Mengli, Liu, Hongrui, He, Guiqiong, Kaplan, David R., Ellis, James, Yang, Guang
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181744/
https://ncbi.nlm.nih.gov/pubmed/32332750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15941-2
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