Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells

Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal and differentiation of neural precursor cells (NPCs) in the developing mammalian brain. However, little is known about how metabolic signals instruct gene expression to control NPC homeostasis. Here, we sho...

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Publicado no:Nat Commun
Main Authors: Rodrigues, Deivid Carvalho, Harvey, Emily M., Suraj, Rejitha, Erickson, Sarah L., Mohammad, Lamees, Ren, Mengli, Liu, Hongrui, He, Guiqiong, Kaplan, David R., Ellis, James, Yang, Guang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181744/
https://ncbi.nlm.nih.gov/pubmed/32332750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15941-2
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