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Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages

DNA damage regulated autophagy modulator 1 (DRAM1) is a stress-inducible regulator of autophagy and cell death. DRAM1 has been implicated in cancer, myocardial infarction, and infectious diseases, but the molecular and cellular functions of this transmembrane protein remain poorly understood. Previo...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Zhang, Rui, Varela, Monica, Forn-Cuní, Gabriel, Torraca, Vincenzo, van der Vaart, Michiel, Meijer, Annemarie H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181687/
https://ncbi.nlm.nih.gov/pubmed/32332700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2477-1
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