Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

Gene rv3722c of Mycobacterium tuberculosis is essential for in vitro growth, and encodes a putative pyridoxal phosphate-binding protein of unknown function. Here we use metabolomic, genetic and structural approaches to show that Rv3722c is the primary aspartate aminotransferase of M. tuberculosis, a...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Jansen, Robert S., Mandyoli, Lungelo, Hughes, Ryan, Wakabayashi, Shoko, Pinkham, Jessica T., Selbach, Bruna, Guinn, Kristine M., Rubin, Eric J., Sacchettini, James C., Rhee, Kyu Y.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181641/
https://ncbi.nlm.nih.gov/pubmed/32327655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15876-8
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