Dendritic cell paucity leads to dysfunctional immune surveillance in pancreatic cancer

Herein, we utilized spontaneous models of pancreatic and lung cancer to examine how neoantigenicity shapes tumor immunity and progression. As expected, neoantigen expression during lung adenocarcinoma development leads to T cell-mediated immunity and disease restraint. By contrast, neoantigen expres...

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Gepubliceerd in:Cancer Cell
Hoofdauteurs: Hegde, Samarth, Krisnawan, Varintra E., Herzog, Brett H., Zuo, Chong, Breden, Marcus A., Knolhoff, Brett L., Hogg, Graham D., Tang, Jack P., Baer, John M., Mpoy, Cedric, Lee, Kyung Bae, Alexander, Katherine A., Rogers, Buck E., Murphy, Kenneth M., Hawkins, William G., Fields, Ryan C., DeSelm, Carl J., Schwarz, Julie K., DeNardo, David G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181337/
https://ncbi.nlm.nih.gov/pubmed/32183949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.02.008
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