The development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion

OBJECTIVE: We investigated how pancreatic cancer developed resistance to FAK inhibition over time. DESIGN: Pancreatic ductal adenocarcinoma (PDAC) tumors from KPC mice (p48-CRE; LSL-KRas(G12D/wt); p53(flox/wt)) treated with FAK inhibitor were analyzed for the activation of a compensatory survival pa...

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Detaylı Bibliyografya
Yayımlandı:Gut
Asıl Yazarlar: Jiang, Hong, Liu, Xiuting, Knolhoff, Brett L., Hegde, Samarth, Lee, Kyung Bae, Jiang, Hongmei, Fields, Ryan C., Pachter, Jonathan A., Lim, Kian-Huat, DeNardo, David G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7167297/
https://ncbi.nlm.nih.gov/pubmed/31076405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2018-317424
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