Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats

Histamine H3 receptors (H3Rs) are involved in several neuropsychiatric diseases including epilepsy. Therefore, the effects of H3R antagonist E177 (5 and 10 mg/kg, intraperitoneal (i.p.)) were evaluated on the course of kindling development, kindling-induced memory deficit, oxidative stress levels (g...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Alachkar, Alaa, Azimullah, Sheikh, Lotfy, Mohamed, Adeghate, Ernest, Ojha, Shreesh K., Beiram, Rami, Łażewska, Dorota, Kieć-Kononowicz, Katarzyna, Sadek, Bassem
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181068/
https://ncbi.nlm.nih.gov/pubmed/32235506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25071575
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