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One-pot Synthesis of Heterodimeric Agonists that Activate the Canonical Wnt Signaling Pathway
Fragment antigen-binding domains (Fabs) from anti-Frizzled and anti-LRP6 monoclonal antibodies were conjugated using SpyTag-SpyCatcher chemistry via a one-pot reaction. The resulting synthetic heterodimeric agonist outperformed the natural ligand, Wnt-3a, in activating canonical Wnt signaling in mam...
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| 出版年: | Chem Commun (Camb) |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7179975/ https://ncbi.nlm.nih.gov/pubmed/32119023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cc00920b |
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