Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

SARS-CoV-2 is the etiological agent responsible for the global COVID-19 outbreak. The main protease (M(pro)) of SARS-CoV-2 is a key enzyme that plays a pivotal role in mediating viral replication and transcription. We designed and synthesized two lead compounds (11a and 11b) targeting M(pro). Both e...

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Publicado no:Science
Main Authors: Dai, Wenhao, Zhang, Bing, Su, Haixia, Li, Jian, Zhao, Yao, Xie, Xiong, Jin, Zhenming, Liu, Fengjiang, Li, Chunpu, Li, You, Bai, Fang, Wang, Haofeng, Cheng, Xi, Cen, Xiaobo, Hu, Shulei, Yang, Xiuna, Wang, Jiang, Liu, Xiang, Xiao, Gengfu, Jiang, Hualiang, Rao, Zihe, Zhang, Lei-Ke, Xu, Yechun, Yang, Haitao, Liu, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179937/
https://ncbi.nlm.nih.gov/pubmed/32321856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abb4489
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