Novel Insights into Plasmodium vivax Therapeutic Failure: CYP2D6 Activity and Time of Exposure to Malaria Modulate the Risk of Recurrence

Plasmodium vivax relapse is one of the major causes of sustained global malaria transmission. Primaquine (PQ) is the only commercial drug available to prevent relapses, and its efficacy is dependent on metabolic activation by cytochrome P450 2D6 (CYP2D6). Impaired CYP2D6 function, caused by allelic...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Silvino, Ana Carolina Rios, Kano, Flora Satiko, Costa, Marcelo Azevedo, Fontes, Cor Jesus Fernandes, Soares, Irene Silva, de Brito, Cristiana Ferreira Alves, Carvalho, Luzia Helena, Sousa, Tais Nobrega
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2020
Teme:
Epidemiology and Surveillance
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179649/
https://ncbi.nlm.nih.gov/pubmed/32122891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02056-19
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