Novel Insights into Plasmodium vivax Therapeutic Failure: CYP2D6 Activity and Time of Exposure to Malaria Modulate the Risk of Recurrence

Plasmodium vivax relapse is one of the major causes of sustained global malaria transmission. Primaquine (PQ) is the only commercial drug available to prevent relapses, and its efficacy is dependent on metabolic activation by cytochrome P450 2D6 (CYP2D6). Impaired CYP2D6 function, caused by allelic...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Silvino, Ana Carolina Rios, Kano, Flora Satiko, Costa, Marcelo Azevedo, Fontes, Cor Jesus Fernandes, Soares, Irene Silva, de Brito, Cristiana Ferreira Alves, Carvalho, Luzia Helena, Sousa, Tais Nobrega
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Epidemiology and Surveillance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179649/
https://ncbi.nlm.nih.gov/pubmed/32122891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02056-19
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