Novel Insights into Plasmodium vivax Therapeutic Failure: CYP2D6 Activity and Time of Exposure to Malaria Modulate the Risk of Recurrence

Plasmodium vivax relapse is one of the major causes of sustained global malaria transmission. Primaquine (PQ) is the only commercial drug available to prevent relapses, and its efficacy is dependent on metabolic activation by cytochrome P450 2D6 (CYP2D6). Impaired CYP2D6 function, caused by allelic...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Silvino, Ana Carolina Rios, Kano, Flora Satiko, Costa, Marcelo Azevedo, Fontes, Cor Jesus Fernandes, Soares, Irene Silva, de Brito, Cristiana Ferreira Alves, Carvalho, Luzia Helena, Sousa, Tais Nobrega
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Epidemiology and Surveillance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179649/
https://ncbi.nlm.nih.gov/pubmed/32122891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02056-19
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