Novel Insights into Plasmodium vivax Therapeutic Failure: CYP2D6 Activity and Time of Exposure to Malaria Modulate the Risk of Recurrence

Plasmodium vivax relapse is one of the major causes of sustained global malaria transmission. Primaquine (PQ) is the only commercial drug available to prevent relapses, and its efficacy is dependent on metabolic activation by cytochrome P450 2D6 (CYP2D6). Impaired CYP2D6 function, caused by allelic...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Silvino, Ana Carolina Rios, Kano, Flora Satiko, Costa, Marcelo Azevedo, Fontes, Cor Jesus Fernandes, Soares, Irene Silva, de Brito, Cristiana Ferreira Alves, Carvalho, Luzia Helena, Sousa, Tais Nobrega
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Epidemiology and Surveillance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179649/
https://ncbi.nlm.nih.gov/pubmed/32122891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02056-19
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados