Whole-Cell Phenotypic Screening of Medicines for Malaria Venture Pathogen Box Identifies Specific Inhibitors of Plasmodium falciparum Late-Stage Development and Egress

We report a systematic, cellular phenotype-based antimalarial screening of the Medicines for Malaria Venture Pathogen Box collection, which facilitated the identification of specific blockers of late-stage intraerythrocytic development of Plasmodium falciparum. First, from standard growth inhibition...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Patra, Alok Tanala, Hingamire, Tejashri, Belekar, Meenakshi A., Xiong, Aoli, Subramanian, Gowtham, Bozdech, Zbynek, Preiser, Peter, Shanmugam, Dhanasekaran, Chandramohanadas, Rajesh
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179631/
https://ncbi.nlm.nih.gov/pubmed/32071059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01802-19
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