Targeted Phenotypic Screening in Plasmodium falciparum and Toxoplasma gondii Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules

The Malaria Box collection includes 400 chemically diverse small molecules with documented potency against malaria parasite growth, but the underlying modes of action are largely unknown. Using complementary phenotypic screens against Plasmodium falciparum and Toxoplasma gondii, we report phenotype-...

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Detalhes bibliográficos
Publicado no:mSphere
Main Authors: Subramanian, Gowtham, Belekar, Meenakshi A., Shukla, Anurag, Tong, Jie Xin, Sinha, Ameya, Chu, Trang T. T., Kulkarni, Akshay S., Preiser, Peter R., Reddy, D. Srinivasa, Tan, Kevin S. W., Shanmugam, Dhanasekaran, Chandramohanadas, Rajesh
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770543/
https://ncbi.nlm.nih.gov/pubmed/29359192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00534-17
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