Role of Arginine 214 in the Substrate Specificity of OXA-48

Increasing numbers of variants of the carbapenem-hydrolyzing class D β-lactamase OXA-48 are identified in Enterobacterales worldwide. Among them, OXA-181 and OXA-232 are of particular interest, as they differ from each other by a single amino acid substitution at position 214 (R in OXA-181 and S in...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Oueslati, Saoussen, Retailleau, Pascal, Marchini, Ludovic, Berthault, Camille, Dortet, Laurent, Bonnin, Rémy A., Iorga, Bogdan I., Naas, Thierry
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179614/
https://ncbi.nlm.nih.gov/pubmed/32071047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02329-19
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