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Thiostrepton Reactivates Latent HIV-1 through the p-TEFb and NF-κB Pathways Mediated by Heat Shock Response
Antiretroviral therapy (ART) suppresses HIV-1 replication but fails to cure the infection. The presence of an extremely stable viral latent reservoir, primarily in resting memory CD4(+) T cells, remains a major obstacle to viral eradication. The “shock and kill” strategy targets these latently infec...
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| Опубликовано в: : | Antimicrob Agents Chemother |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7179580/ https://ncbi.nlm.nih.gov/pubmed/32094131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02328-19 |
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