Activation of Heme Oxygenase Expression by Cobalt Protoporphyrin Treatment Prevents Pneumonic Plague Caused by Inhalation of Yersinia pestis

Pneumonic plague, caused by the Gram-negative bacteria Yersinia pestis, is an invasive, rapidly progressing disease with poor survival rates. Following inhalation of Y. pestis, bacterial invasion of the lungs and a tissue-damaging inflammatory response allows vascular spread of the infection. Conseq...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Willix, Joshua L., Stockton, Jacob L., Olson, Rachel M., Anderson, Paul E., Anderson, Deborah M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179272/
https://ncbi.nlm.nih.gov/pubmed/32015027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01819-19
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