Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway

Intestinal ischemia-reperfusion (I/R) injury is a life-threatening vascular emergency and has long been a disturbing problem for surgeons. Oxidative stress is considered a vital factor in I/R injury. Metformin has anti-oxidative properties and protects against I/R injury. The present study aimed to...

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Publicat a:Redox Biol
Autors principals: Jia, Yifan, Cui, Ruixia, Wang, Cong, Feng, Yang, Li, Zeyu, Tong, Yingmu, Qu, Kai, Liu, Chang, Zhang, Jingyao
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7178548/
https://ncbi.nlm.nih.gov/pubmed/32330868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101534
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