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Evaluation of the Potential Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Niemann–Pick Disease, Type C1

Niemann–Pick disease, type C1, is a cholesterol storage disease where unesterified cholesterol accumulates intracellularly. In the cerebellum this causes neurodegeneration of the Purkinje neurons that die in an anterior-to-posterior and time-dependent manner. This results in cerebellar ataxia as one...

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Publicat a:Int J Mol Sci
Autors principals: Cawley, Niamh X., Lyons, Anna T., Abebe, Daniel, Wassif, Christopher A., Porter, Forbes D.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7178166/
https://ncbi.nlm.nih.gov/pubmed/32244519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21072430
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