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CRISPR Interference–Potential Application in Retinal Disease

The treatment of dominantly inherited retinal diseases requires silencing of the pathogenic allele. RNA interference to suppress gene expression suffers from wide-spread off-target effects, while CRISPR-mediated gene disruption creates permanent changes in the genome. CRISPR interference uses a cata...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Mol Sci
Prif Awduron: Peddle, Caroline F., Fry, Lewis E., McClements, Michelle E., MacLaren, Robert E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7177328/
https://ncbi.nlm.nih.gov/pubmed/32230903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21072329
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