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CRISPR Interference–Potential Application in Retinal Disease
The treatment of dominantly inherited retinal diseases requires silencing of the pathogenic allele. RNA interference to suppress gene expression suffers from wide-spread off-target effects, while CRISPR-mediated gene disruption creates permanent changes in the genome. CRISPR interference uses a cata...
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| Опубликовано в: : | Int J Mol Sci |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
MDPI
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7177328/ https://ncbi.nlm.nih.gov/pubmed/32230903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21072329 |
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