Upregulation of TRPC6 Mediated by PAX6 Hypomethylation Is Involved in the Mechanical Allodynia Induced by Chemotherapeutics in Dorsal Root Ganglion

BACKGROUND: Although the action mechanism of antineoplastic agents is different, oxaliplatin, paclitaxel, or bortezomib as first-line antineoplastic drugs can induce painful neuropathy. In rodents, mechanical allodynia is a common phenotype of painful neuropathy for 3 chemotherapeutics. However, whe...

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Vydáno v:Int J Neuropsychopharmacol
Hlavní autoři: Zhang, Xiang-Zhong, Luo, De-Xing, Bai, Xiao-Hui, Ding, Huan-Huan, Liu, Meng, Deng, Jie, Mai, Jing-Wen, Yang, Yan-Ling, Zhang, Su-Bo, Ruan, Xiang-Cai, Zhang, Xue-Qin, Xin, Wen-Jun, Xu, Ting
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Regular Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7177167/
https://ncbi.nlm.nih.gov/pubmed/32124922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyaa014
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