Ligand-Mediated Targeting of Cytokine Interleukin-27 Enhances Its Bioactivity In Vivo

We have examined the role of a novel targeted cytokine, interleukin-27 (IL-27), modified at the C terminus with a dual targeting and therapeutic heptapeptide, in treating prostate cancer. IL-27 has shown promise in halting tumor growth and mediating tumor regression in several cancer models, includi...

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Udgivet i:Mol Ther Methods Clin Dev
Main Authors: Figueiredo, Marxa L., Figueiredo Neto, Manoel, Salameh, Janelle Wes, Decker, Richard E., Letteri, Rachel, Chan-Seng, Delphine, Emrick, Todd
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7177159/
https://ncbi.nlm.nih.gov/pubmed/32346551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.03.022
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