C−H Bond Cleavage Is Rate-Limiting for Oxidative C−P Bond Cleavage by the Mixed Valence Diiron-Dependent Oxygenase PhnZ

PhnZ utilizes a mixed valence diiron(II/III) cofactor and O(2) to oxidatively cleave the carbon–phosphorus bond of (R)-2-amino-1-hydroxyethylphosphonic acid to form glycine and orthophosphate. The active site residues Y24 and E27 are proposed to mediate induced-fit recognition of the substrate and a...

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Vydáno v:Biochemistry
Hlavní autoři: Gama, Simanga R., Yan Lo, Becky Suet, Séguin, Jacqueline, Pallitsch, Katharina, Hammerschmidt, Friedrich, Zechel, David L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176486/
https://ncbi.nlm.nih.gov/pubmed/31046250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00145
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